Amsacrine
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Amsacrine(Amsidine,m-AMSA)是一种拓扑异构酶Ⅱ抑制剂[1].
Amsacrine是一种抗肿瘤化疗药物,用于治疗某些淋巴瘤与急性白血病.多种癌细胞系均对Amsacrine敏感,Amsacrine对3种膀胱癌细胞系(HT1376\RT112和RT4)和3种睾丸癌细胞系(833K\Susa和GH)的IC50值分别为190.2 ± 27.4 ng/ml\46.1 ± 3.9 ng/ml\22.6 ± 3.1 ng/ml\11.8 ± 2.0 ng/ml\5.0 ± 0.4 ng/ml和11.7 ± 1.5 ng/ml.据发现,与膀胱细胞系相比,睾丸癌细胞系对Amsacrine的抑制作用更敏感[1].
参考文献：
[1] Nelson EM, Tewey KM, Liu LF. Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide. Proc Natl Acad Sci U S A. 1984 Mar;81(5):1361-5.
| Storage | Store at -20°C |
| M.Wt | 393.46 |
| Cas No. | 51264-14-3 |
| Formula | C21H19N3O3S |
| Solubility | Soluble in DMSO |
| Chemical Name | N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide |
| SDF | Download SDF |
| Canonical SMILES | COC1=C(C=CC(=C1)NS(=O)(=O)C)NC2=C3C=CC=CC3=NC4=CC=CC=C42 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
