Ambrisentan
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Ambrisentan是ETA受体的选择性拮抗剂,Ki值为1 nM[1].
Ambrisentan是一种有口服活性的二苯基丙酸衍生物.该物质常用于治疗肺动脉高压.在体外试验中,ambrisentan对CHO细胞中表达的ETA受体的亲和性比ETB受体更高,Ki值分别为1 nM和195 nM.Ambrisentan对完整细胞中的重组人ET受体的选择性更高,对ETA和ETB受体的Ki值分别为0.63 nM和48.7 nM.作为ETA受体的选择性拮抗剂,ambrisentan比非选择性受体拮抗剂更为优先,因其对内皮细胞中的ETB受体具有特异性的血管扩张剂和清除功能维持.此外,ambrisentan也可能用于防止再灌注损伤,也适用于治疗脑血管疾病[1,2].
参考文献：
[1] Vatter H, Seifert V. Ambrisentan, a Non-peptide Endothelin Receptor Antagonist. Cardiovascular drug reviews, 2006, 24(1): 63-76.
[2] Barst R J. A review of pulmonary arterial hypertension: role of ambrisentan. Vascular health and risk management, 2007, 3(1): 11.
| Storage | Store at -20°C |
| M.Wt | 378.42 |
| Cas No. | 177036-94-1 |
| Formula | C22H22N2O4 |
| Solubility | insoluble in H2O; ≥18.92 mg/mL in DMSO; ≥2.85 mg/mL in EtOH with ultrasonic |
| Chemical Name | (2S)-2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoic acid |
| SDF | Download SDF |
| Canonical SMILES | CC1=CC(=NC(=N1)OC(C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)C |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
