Alendronate
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Alendronate是骨吸收抑制剂,IC50值为2 nM[1].
Alendronate是一种二磷酸盐.该物质被开发为针对多种骨骼疾病,包括骨质疏松症和佩吉特氏病以及肿瘤骨病的药物.Alendronate可结合骨质以阻止其被破骨细胞消化,从而抑制骨吸收.该物质不仅可影响破骨细胞功能,还能调控细胞形态.在体外试验中,alendronate具有抗消溶效果,作用于破骨细胞悬浮液的IC50值为2 nM.在组织培养物中,alendronate可抑制胚胎长骨和培养的颅骨的吸收[1,2].
参考文献：
[1] Sahni M, Guenther H L, Fleisch H, et al. Bisphosphonates act on rat bone resorption through the mediation of osteoblasts. Journal of Clinical Investigation, 1993, 91(5): 2004.
[2] Bell N H, Johnson R H. Bisphosphonates in the treatment of osteoporosis. Endocrine, 1997, 6(2): 203-206.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 325.12 |
| Cas No. | 121268-17-5 |
| Formula | C4H18NNaO10P2 |
| Solubility | insoluble in DMSO; insoluble in EtOH; ≥5.57 mg/mL in H2O |
| Chemical Name | sodium hydrogen(4-amino-1-hydroxy-1-phosphonobutyl)phosphonate trihydrate |
| SDF | Download SDF |
| Canonical SMILES | [O-]P(O[H])(C(O[H])(C([H])([H])C([H])([H])C([H])([H])N([H])[H])P(O[H])(O[H])=O)=O.[H]O[H].[H]O[H].[H]O[H].[Na+] |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
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