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A939572

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Catalog No.
B3607
硬脂酰辅酶A去饱和酶1(SCD1)抑制剂
组合的产品项目
规格价格库存 数量
10mM (in 1mL DMSO)
¥ 2,100.00
现货
10mg
¥ 1,000.00
现货
50mg
¥ 4,250.00
现货

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Background

A939572 is a potent and orally bioavailable inhibitor of stearoyl-CoA desaturase1 (SCD1) with IC50 value of 37nM [1].

SCD is a microsomal enzyme that catalyzes the biosynthesis of monounsaturated fatty acids. One member of SCD family, SCD1, is regulated by dietary and hormonal factors and is proved to play an important role in lipid metabolism and body weight control. Thus, SCD1 is a target for the treatment of obesity and diabetes. A939572 is a synthetic inhibitor of SCD1 with improved inhibitory activity and lipophilicity than its parent compound. It shows inhibition of mouse SCD1 and human SCD1 with IC50 values of

References:
[1] Xin Z, Zhao H, Serby M D, et al. Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors. Bioorganic & medicinal chemistry letters, 2008, 18(15): 4298-4302.

文献引用

1. Magtanong L, Ko PJ, et al. "Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State." Cell Chem Biol. 2018 Dec 11. pii:S2451-9456(18)30438-0. PMID:30686757

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt387.86
Cas No.1032229-33-6
FormulaC20H22ClN3O3
Solubility≥17.15mg/mL in DMSO
Chemical Name4-(2-chlorophenoxy)-N-(3-(methylcarbamoyl)phenyl)piperidine-1-carboxamide
SDFDownload SDF
Canonical SMILESCNC(C1=CC(NC(N2CCC(OC3=CC=CC=C3Cl)CC2)=O)=CC=C1)=O
运输条件试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

试验操作

动物实验 [1]:

动物模型

ob/ob小鼠

给药剂量

10 mg/kg;每天2次

实验结果

在ob/ob小鼠中,A939572降低去饱和指数 (18:0/18:1n9)。此外,A939572呈剂量依赖性地降低甘油三酯的去饱和指数。

注意事项

请于室内测试所有化合物的溶解度。虽然化合物的实际溶解度可能与其理论值略有不同,但仍处于实验系统误差的允许范围内。

References:

[1]. Xin Z, Zhao H, Serby M D, et al. Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors. Bioorganic & medicinal chemistry letters, 2008, 18(15): 4298-4302.

质量控制

化学结构

A939572

相关生物数据

A939572