4-(n-nonyl) Benzeneboronic Acid
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
IC50: 9.1 nM
4-(n-nonyl) Benzeneboronic acid is a dual FAAH inhibitor.
Fatty acid amide hydrolase (FAAH), a membrane-bound enzyme of the endocannabinoid system, has been identified as a potential target for therapeutic agents in the treatment of various medical conditions, such as inflammation and pain. FAAH and monoglyceride lipase (MGL) have been reported to be the primary enzyme responsible for the hydrolysis of endocannabinoid N-arachidonoyl ethanolamide (AEA), which is a key lipid messenger in the brain and periphery.
In vitro: 4-(n-Nonyl) benzeneboronic acid was synthezed as a potent inhibitor of FAAH, with an IC50 of 9.1 nM. 4-(n-Nonyl) benzeneboronic acid was also found to be able to inhibit MAGL, which could hydrolyze 2-arachidonoyl glycerol, but at around 1000-fold higher concentration. Moreover, it was found that as the most potent para-substituted compound, 4-(n-Nonyl) benzeneboronic acid showed rather high pKa of 9.1. In addition, the molecular docking was utilized to gain insight on the FAAH binding mode of 4-(n-Nonyl) benzeneboronic acid and a putative binding mode was observed [1].
In vivo: Up to now, there is no animal in vivo data reported.
Clinical trial: So far, no clinical study has been conducted.
Reference:
[1] Minkkil, A. ,Saario, S.M.,Ksnnen, H., et al. Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. Journal of Medicinal Chemistry 51, 7057-7060 (2008).
Storage | Store at -20°C |
M.Wt | 248.2 |
Cas No. | 256383-45-6 |
Formula | C15H25BO2 |
Solubility | insoluble in H2O; ≥11.75 mg/mL in DMSO; ≥25.1 mg/mL in EtOH |
Chemical Name | B-(4-nonylphenyl)-boronic acid |
SDF | Download SDF |
Canonical SMILES | CCCCCCCCCC1=CC=C(B(O)O)C=C1 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
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