Triptonide
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 358.39 |
| Cas No. | 38647-11-9 |
| Formula | C20H22O6 |
| Synonyms | NSC 165677; PG 492 |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥16.35 mg/mL in DMSO |
| Chemical Name | (5bS,6aS,7aS,8aS,9aS,9bS,10aS,10bS)-8a-isopropyl-10b-methyl-1,5b,6,6a,8a,9a,9b,10b-otahydrotris(oxireno)[2',3':4b,5;2'',3'':6,7;2''',3''':8a,9]phenanthro[1,2-c]furan-3,8(2H,5H)-dione |
| SDF | Download SDF |
| Canonical SMILES | CC([C@]12[C@@H](O2)[C@H]3[C@@]4(O3)[C@]5(CCC6=C([C@]5([H])C[C@H]7[C@@]4(O7)C1=O)COC6=O)C)C |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Cell experiment:[1] | |
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Cell lines |
Human B-lymphoma Raji and T-lymphoma Jurkat cell lines |
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Reaction Conditions |
0 ~ 80 nM for 3 or 6 days |
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Applications |
These two lymphoma cell lines were very sensitive to triptonide in a dose-dependent manner, with the IC50 of 11.4 nM at 3 days and 5.7 nM at 6 days in B-lymphoma Raji cells, and 11.1 nM at 3 days and 4.8 nM at 6 days in T-lymphoma Jurkat cells, respectively. |
| Animal experiment:[1] | |
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Animal models |
Eight-week-old female NOD/SCID mice (18 ~ 22 g) xenografted with Raji cells |
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Dosage form |
5 mg/kg Once daily by intraperitoneal injection for 34 days |
|
Applications |
Triptonide at a dose of 5 mg/kg/day almost completely inhibited the lymphoma growth in human lymphoma cells-xenografted mice without obvious side effects. Moreover, the tumors in 6 mice among the 8 xenografted mice were completely eradicated in vivo. |
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Note |
The technical data provided above is for reference only. |
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References: 1. Yang P, Dong F, Zhou Q. Triptonide acts as a novel potent anti-lymphoma agent with low toxicity mainly through inhibition of proto-oncogene Lyn transcription and suppression of Lyn signal pathway. Toxicology Letters, 2017, 278: 9-17. |
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质量控制和MSDS
- 批次:
化学结构
