Recombinant Human IL-6, Tag Free
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
白细胞介素-6 (IL-6)是一种多功能的α-螺旋细胞因子,可调节细胞生长和各种组织的分化,尤其以其在免疫反应和急性期反应中的作用而闻名。IL-6蛋白是由包括T细胞和巨噬细胞在内的多种细胞类型分泌的磷酸化和可变糖基化分子。它通过其异质二聚体受体发挥作用,该受体由IL-6R和泛在表达的糖蛋白13(gp13)组成,前者缺乏酪氨酸/激酶结构域,与IL-6结合的亲和力低。IL-6R复合物具有高亲和力,从而传递信号。IL-6还参与造血、骨代谢和癌症进展,在指导从先天免疫到获得性免疫的过渡中发挥重要作用。
参考文献:
1. Rose-John S, Waetzig GH, Scheller J, Grötzinger J, Seegert D. The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin Ther Targets. 2007 May;11(5):613-24. doi: 10.1517/14728222.11.5.613. PMID: 17465721.
别称 |
IL6, Interleukin-6, BSF2, HSF, IFNB2. |
Gene ID |
3569 |
Accession # |
P05231-1 |
蛋白序列 |
Val 30 - Met 212 |
分子量 |
20.8 kDa |
来源 |
293T cells |
生物活性 |
以下数据来自于小鼠CTLL-2细胞的剂量依赖性实验: ED50:< 0.1 ng/mL 放射性比度:> 1x107units/mg. |
产品形式 |
该蛋白以溶解于PBS缓冲液的形式提供。 |
存储说明 |
此产品可稳定存在于如下条件中: 4°C保存一周; -20°C保存3个月。 请避免多次反复冻融。 |