BP-1-102
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
BP-1-102是一种口服活性、有效和特异的STAT3抑制剂。BP-1-102与Stat3结合（Kd：504 nM），然后阻断Stat3-磷酸酪氨酸（pTyr）肽的相互作用和Stat3的激活（4-6.8 μM），并选择性地抑制依赖Stat3的肿瘤细胞的迁移、生存、生长和侵袭。BP-1-102介导的对肿瘤细胞中异常活跃的Stat3的抑制抑制了c-Myc、Bcl-xL、Cyclin D1、Survivin和VEGF的表达[1]。
参考文献：
[1]. Zhang X, Yue P, Page BD, Li T, Zhao W, Namanja AT, Paladino D, Zhao J, Chen Y, Gunning PT, Turkson J. Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9623-8. doi: 10.1073/pnas.1121606109. Epub 2012 May 23. PMID: 22623533; PMCID: PMC3386073.
| Storage | Store at -20°C |
| M.Wt | 626.59 |
| Cas No. | 1334493-07-0 |
| Formula | C29H27F5N2O6S |
| Solubility | ≥64.8 mg/mL in DMSO |
| Chemical Name | 4-(N-(4-cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid |
| SDF | Download SDF |
| Canonical SMILES | O=C(C1=CC=C(N(C(CN(S(=O)(C2=C(F)C(F)=C(F)C(F)=C2F)=O)C)=O)CC3=CC=C(C4CCCCC4)C=C3)C=C1O)O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
