Chromatin/Epigenetics - Cancer - HIV Infections - Prostate Cancer - Leukemia
Epigenetics is the heritable modifications in gene expression that is not associated with changes in DNA sequence. Epigenetic modifications occur mostly on DNA or on the histone octamer. There are several types of epigenetics modifications, DNA methylation by DNA-methyl transferase (DNMT) and covalent modification of histones (e.g. acetylation, methylation, phosphorylation and ubiquitination). Histone acetylation by histone acetyltransferases (HATs) is involved in transcriptional activation, whereas histone deacetylation by histone deacetylases (HDACs) is connected with transcriptional repression. Histone demethylation is associated with lysine-specific demethylase (LSD) and JmjC domain containing histone demethylase (JHDM).
The nucleosome is consisted of four histone proteins (H2A, H2B, H3, and H4), they are primary building block of chromatin. The addition and removal of specific chemical groups refers to as epigenetic marks, it regulates chromatin structure and affects gene expression. Moreover, RNA is intimately involved in the formation of a repressive chromatin state.
Epigenetic mechanism responds to environmental changes at the cellular level and thus influences cellular plasticity. Chromatin and epigenetic regulation play a significant role in the programming of the genome during development and stress response, defects in epigenetics can lead to cancer, inflammation and metabolic disorders etc.
- B3272 InauhzinTarget: Sir2-like Family Deacetylases (Sirtuins)Summary: SIRT1抑制剂
- B6004 PX-478 2HClTarget: Hypoxia Inducible Factors (HIFs)Summary: HIF-1α抑制剂
- B5916 Chidamide1 CitationTarget: HDACSummary: HDAC抑制剂
- B5879 GSK28795521 CitationTarget: LSDSummary: LSD1抑制剂
- A8712 MCB-613Target: SrcSummary: 类固醇受体共激活因子(SRC)刺激物
- B4989 EPZ015666Target: Protein Arginine MethyltransferasesSummary: PRMT5抑制剂
- B4894 SP2509Target: Histone DemethylasesSummary: 新型LSD1拮抗剂
- B4890 HPOB1 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC6抑制剂
- B1581 EPZ004777 HClTarget: DOT1LSummary: DOT1L抑制剂
- B1577 C6461 CitationTarget: p300Summary: HAT p300-CBP抑制剂