Chromatin/Epigenetics
Epigenetics is the heritable modifications in gene expression that is not associated with changes in DNA sequence. Epigenetic modifications occur mostly on DNA or on the histone octamer. There are several types of epigenetics modifications, DNA methylation by DNA-methyl transferase (DNMT) and covalent modification of histones (e.g. acetylation, methylation, phosphorylation and ubiquitination). Histone acetylation by histone acetyltransferases (HATs) is involved in transcriptional activation, whereas histone deacetylation by histone deacetylases (HDACs) is connected with transcriptional repression. Histone demethylation is associated with lysine-specific demethylase (LSD) and JmjC domain containing histone demethylase (JHDM).
The nucleosome is consisted of four histone proteins (H2A, H2B, H3, and H4), they are primary building block of chromatin. The addition and removal of specific chemical groups refers to as epigenetic marks, it regulates chromatin structure and affects gene expression. Moreover, RNA is intimately involved in the formation of a repressive chromatin state.
Epigenetic mechanism responds to environmental changes at the cellular level and thus influences cellular plasticity. Chromatin and epigenetic regulation play a significant role in the programming of the genome during development and stress response, defects in epigenetics can lead to cancer, inflammation and metabolic disorders etc.
- B6184 BI-9564Summary: BRD9/7特异性抑制剂
- B6183 MS0231 CitationSummary: I型PRMTs抑制剂
- B6182 GSK591Target: PRMTSummary: PRMT5抑制剂
- B6169 I-BRD9Summary: BRD9抑制剂
- B6168 OICR-9429Summary: Wdr5-MLL相互作用拮抗剂
- B6120 Adox中文名: 腺苷二醛Summary: 间接甲基转移酶抑制剂
- B6119 LLY507Summary: SMYD2抑制剂
- B6088 EPZ020411Summary: PRMT6抑制剂
- B6085 AMI5/Eosin Y disodium saltSummary: 蛋白甲基转移酶抑制剂/伊红,用于苏木精伊红染色(HE染色)
- B6084 AS8351Summary: 组蛋白去甲基化酶抑制剂