Adox
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Adenosine dialdehyde（AdOx）是一种间接甲基转移酶抑制剂。
组蛋白甲基转移酶是通过向特定组蛋白精氨酸或赖氨酸残基添加甲基来催化组蛋白赖氨酸和精氨酸的甲基化的一组酶。
体外：先前基于细胞的研究表明，在不同类型的测试细胞中，用甲基转移酶抑制剂Adenosine dialdehyde（AdOx）处理细胞可导致细胞周期停滞和死亡。此外，细胞死亡和表型外显的e形式显著依赖于AdOx的浓度。通过生物化学和形态学标准测量，结果显示较低的AdOx浓度可导致G2停滞并且主要引起凋亡。相比之下，更高浓度的AdOx导致一种新的和迄今未有描述的细胞死亡形式，其特征在于不同的、caspase非依赖性的细胞形状改变，具有明显的细胞核突起、肌动蛋白聚集、细胞质延伸，以及不完全的染色质凝聚[1]。
体内：目前尚无动物数据报道。
临床试验：到目前为止，AdOx仍处于临床前研究阶段。
参考文献：
[1] Schwerk C,Schulze-Osthoff K. Methyltransferase inhibition induces p53-dependent apoptosis and a novel form of cell death. Oncogene.2005 Oct 27;24(47):7002-11.
- 1. Mengyuan He, Jiarong Guo, et al. "A highly selective electrochemical assay based on the Sakaguchi reaction for the detection of protein arginine methylation state." Electrochemistry Communications;Volume 118, September 2020, 106808.
- 2. Bai Y, Wang W, et al. "C1QBP Promotes Homologous Recombination by Stabilizing MRE11 and Controlling the Assembly and Activation of MRE11/RAD50/NBS1 Complex." Mol Cell. 2019 Jul 9. pii: S1097-2765(19)30479-4. PMID: 31353207
| Physical Appearance | A powder |
| Storage | Store at -20°C |
| M.Wt | 265.23 |
| Cas No. | 34240-05-6 |
| Formula | C10H11N5O4 |
| Solubility | Soluble in DMSO |
| Chemical Name | 2-(1-(6-amino-9H-purin-9-yl)-2-oxoethoxy)-3-hydroxypropanal |
| SDF | Download SDF |
| Canonical SMILES | O=C(C(OC(CO)C([H])=O)N1C=NC2=C1N=CN=C2N)[H] |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
相关生物数据
相关生物数据
