Proteases - Cell Experiments
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- A8201 Amprenavir (agenerase)中文名: 安瑞那韦Summary: HIV-1蛋白酶抑制剂
- A8203 Ritonavir中文名: 利托那韦Summary: HIV蛋白酶抑制剂
- A8205 Atazanavir1 Citation中文名: 阿扎那韦Summary: HIV蛋白酶抑制剂
- A4038 Alogliptin (SYR-322)1 Citation中文名: 阿格列汀Target: DPP-4Summary: DPP-4抑制剂
- A2585 MG-13226 CitationTarget: ProteasomeSummary: 细胞通透性的、可逆性的蛋白酶体抑制剂。
- A4036 Sitagliptin phosphate monohydrate5 Citation中文名: 磷酸西他列汀一水合物Target: DPP-4Summary: DPP-4抑制剂
- A4032 VX-222 (VCH-222, Lomibuvir)Target: HCV polymeraseSummary: HCV RNA聚合酶抑制剂
- A4031 Telaprevir (VX-950)中文名: 特拉匹韦Target: HCV NS3-4A proteaseSummary: HCV NS3-4A蛋白酶抑制剂
- A8204 Lopinavir中文名: 洛匹那韦Summary: HIV蛋白酶抑制剂
- A4077 BIBR 953 (Dabigatran, Pradaxa)中文名: 达比加群Summary: 强效的、可逆的直接凝血酶抑制剂