Proteases - Animal Experiments
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- A8162 E-64-c中文名: 阿洛司他丁酸Target: cysteine proteaseSummary: 半胱氨酸蛋白酶抑制剂
- A1926 CA 0742 CitationTarget: CathepsinsSummary: Cathepsin B抑制剂
- A4388 XL-8881 CitationTarget: HSP90Summary: Hsp90抑制剂
- A4386 Elesclomol (STA-4783)3 Citation中文名: 伊利司莫Summary: 氧化应激/细胞凋亡诱导剂
- A1920 Z-DEVD-FMK12 CitationTarget: CaspasesSummary: Caspase-3抑制剂
- A4355 Tosedostat (CHR2797)1 Citation中文名: 托舍多特Target: AminopeptidasesSummary: 氨肽酶(Aminopeptidase)抑制剂
- A1904 Boc-D-FMK1 CitationTarget: CaspasesSummary: 广谱caspase抑制剂
- A1903 E 64d4 Citation中文名: 阿洛司他丁Summary: 半胱氨酸蛋白酶抑制剂
- A1901 Q-VD-OPh53 CitationTarget: CaspasesSummary: Pan-caspase抑制剂。
- A4023 LY30394781 CitationTarget: NotchSummary: Notch抑制剂