Proteases - Selective
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- A3253 BMS-6265292 CitationTarget: HIV-1 gp120Summary: HIV-1吸附的抑制剂
- A3244 Bivalirudin TrifluoroacetateTarget: thrombinSummary: 凝血酶抑制剂
- A3126 5-R-Rivaroxaban中文名: 5-R-利伐沙班Target: Factor XaSummary: 因子Xa(FXa)抑制剂
- A8165 Q-VD(OMe)-OPh6 CitationTarget: CaspasesSummary: Pan-caspase抑制剂
- A1926 CA 0742 CitationTarget: CathepsinsSummary: Cathepsin B抑制剂
- A1925 Caspase-3/7 Inhibitor I2 CitationTarget: CaspasesSummary: Caspase-3/7抑制剂
- A1923 Z-VEID-FMK2 CitationTarget: CaspasesSummary: Caspase-6抑制剂
- A1921 Z-DQMD-FMK3 CitationTarget: CaspasesSummary: 细胞渗透性Caspase-3抑制剂
- A4388 XL-8881 CitationTarget: HSP90Summary: Hsp90抑制剂
- A4386 Elesclomol (STA-4783)3 Citation中文名: 伊利司莫Summary: 氧化应激/细胞凋亡诱导剂