Bromodomain
Bromodomains are a family of evolutionarily conserved protein modules of approximately 110 amino acids that have been found in chromatin-associated proteins as well as nuclear histone acetyltransferases (HATs). Besides its role in chromatin remodeling, recent studies have identified that bromodomains, as acetyl-lysine binding domains, are able to recognize and bind ε–N-acetylated lysine residues in histone and non-histone proteins. The nuclear magnetic resonance (NMR) spectroscopic analysis reveals that the chemical structure of bromodomains, consisting of four left-handed α-helices (including αZ, αA, αB and αC) connected by two loops (ZA and BC loops), forms a deep hydrophobic cavity serving as the acetyl-lysine recognition site.
- B5973 PFI 4Summary: BRPF1 Bromodomain抑制剂
- B5887 BET bromodomain inhibitor1 CitationSummary: BRD4抑制剂
- B4918 OXF BD 02Summary: BRD4 bromodomain选择性抑制剂
- B4917 Ischemin sodium saltSummary: CBP bromodomain抑制剂
- B4916 GSK 5959Summary: BRPF1 bromodomain抑制剂
- B4915 BAZ2-ICRSummary: 选择性BAZ2 bromodomain抑制剂
- B4895 OF-1Summary: BRPF1B和BRPF2 bromodomain抑制剂
- B5670 I-BET 151 hydrochloride1 CitationSummary: BET bromodomain抑制剂
- B7744 PFI 3Target: Protein polybromo-1|SMARCA4|SMARCA2Summary: Polybromo 1和SMARCA4抑制剂
- B1081 CPI-2031 CitationSummary: BET bromodomain抑制剂