Chromatin/Epigenetics - Animal Experiments
Epigenetics is the heritable modifications in gene expression that is not associated with changes in DNA sequence. Epigenetic modifications occur mostly on DNA or on the histone octamer. There are several types of epigenetics modifications, DNA methylation by DNA-methyl transferase (DNMT) and covalent modification of histones (e.g. acetylation, methylation, phosphorylation and ubiquitination). Histone acetylation by histone acetyltransferases (HATs) is involved in transcriptional activation, whereas histone deacetylation by histone deacetylases (HDACs) is connected with transcriptional repression. Histone demethylation is associated with lysine-specific demethylase (LSD) and JmjC domain containing histone demethylase (JHDM).
The nucleosome is consisted of four histone proteins (H2A, H2B, H3, and H4), they are primary building block of chromatin. The addition and removal of specific chemical groups refers to as epigenetic marks, it regulates chromatin structure and affects gene expression. Moreover, RNA is intimately involved in the formation of a repressive chromatin state.
Epigenetic mechanism responds to environmental changes at the cellular level and thus influences cellular plasticity. Chromatin and epigenetic regulation play a significant role in the programming of the genome during development and stress response, defects in epigenetics can lead to cancer, inflammation and metabolic disorders etc.
- A4501 Tubacin3 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC6有效的、选择性、可逆的、细胞通透性的抑制剂。
- A4497 PyroxamideTarget: Histone Deacetylases (HDACs)Summary: HDAC1抑制剂
- A4496 NSC 3852Target: Histone Deacetylases (HDACs)Summary: HDAC抑制剂
- A4488 Anacardic acid中文名: 漆树酸Target: Histone Acetyltransferases (HATs)Summary: HAT抑制剂
- A3962 AZD1208Target: PimSummary: PIM激酶抑制剂
- A3958 Veliparib dihydrochloride中文名: 维利帕尼二盐酸盐Target: PARPSummary: PARP-1/PARP-2抑制剂
- A3937 XL019Target: JAKSummary: 有效的JAK2选择性抑制剂
- A3821 SRT2104 (GSK2245840)1 CitationTarget: Sir2-like Family Deacetylases (Sirtuins)Summary: SIRT1激活剂
- A3761 RG2833Target: HDACSummary: 脑渗透性HDAC抑制剂
- A3760 Reversine中文名: 逆转素Target: Aurora KinasesSummary: Aurora激酶抑制剂