Chromatin/Epigenetics - Cell Experiments
Epigenetics is the heritable modifications in gene expression that is not associated with changes in DNA sequence. Epigenetic modifications occur mostly on DNA or on the histone octamer. There are several types of epigenetics modifications, DNA methylation by DNA-methyl transferase (DNMT) and covalent modification of histones (e.g. acetylation, methylation, phosphorylation and ubiquitination). Histone acetylation by histone acetyltransferases (HATs) is involved in transcriptional activation, whereas histone deacetylation by histone deacetylases (HDACs) is connected with transcriptional repression. Histone demethylation is associated with lysine-specific demethylase (LSD) and JmjC domain containing histone demethylase (JHDM).
The nucleosome is consisted of four histone proteins (H2A, H2B, H3, and H4), they are primary building block of chromatin. The addition and removal of specific chemical groups refers to as epigenetic marks, it regulates chromatin structure and affects gene expression. Moreover, RNA is intimately involved in the formation of a repressive chromatin state.
Epigenetic mechanism responds to environmental changes at the cellular level and thus influences cellular plasticity. Chromatin and epigenetic regulation play a significant role in the programming of the genome during development and stress response, defects in epigenetics can lead to cancer, inflammation and metabolic disorders etc.
- A8808 ME0328Target: PARPSummary: PARP抑制剂
- A8807 MK-8745Target: Aurora KinasesSummary: Aurora A的强效选择性抑制剂。
- A8803 RGFP9664 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC3抑制剂
- A8547 Tubastatin A HCl1 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC6(组蛋白去乙酰化酶6)抑制剂
- A8221 EPZ-64385 CitationSummary: EZH2抑制剂
- A4498 SBHA1 CitationTarget: Histone Deacetylases (HDACs)Summary: 细胞渗透性HDAC1/HDAC3抑制剂
- A4492 NU 9056Target: Histone Acetyltransferases (HATs)Summary: KAT5(Tip60)HAT抑制剂
- A4489 TC-A 2317 hydrochlorideTarget: Aurora KinasesSummary: Aurora kinase A抑制剂
- A4544 NSC 87877Target: PTPSummary: Shp2/Shp1 PTP抑制剂
- A4536 Fostriecin sodium saltTarget: PP1|PP2A|Topoisomerases|PP4Summary: 抗肿瘤抗生素