GW311616 hydrochloride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
GW311616 hydrochloride是一种高效的\选择性的\胞内和具有口服生物利用度且长效的人中性粒细胞弹性蛋白酶(HNE)抑制剂,IC50值为22 nM [1].
与其它人类丝氨酸蛋白酶相比,GW311616 hydrochloride对HNE具有选择性,IC50值为22 nM,对胰蛋白酶\组织蛋白酶G和纤溶酶的IC50值大于100 μM,对糜蛋白酶和组织纤维蛋白溶酶原活化剂的IC50值大于3 μM.在HNE酶动力学试验中,GW311616能够抑制HNE,Ki值为0.13 nM.在HWB试验中,GW311616抑制HWB,IC50值为0.67 μM.通过中性粒细胞内弹性蛋白酶活性的测定,GW311616 hydrochloride在狗的血样中表现出剂量-反应和长效的作用[1].
参考文献：
[1] Macdonald SJ1, Dowle MD, Harrison LA, Shah P, Johnson MR, Inglis GG, Clarke GD, Smith RA, Humphreys D, Molloy CR, Amour A, Dixon M, Murkitt G, Godward RE, Padfield T, Skarzynski T, Singh OM, Kumar KA, Fleetwood G, Hodgson ST, Hardy GW, Finch H. The discovery of a potent, intracellular, orally bioavailable,long duration inhibitor of human neutrophil elastase-GW311616A a development candidate. Bioorg Med Chem Lett. 2001 Apr 9;11(7):895-8.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 433.99 |
| Cas No. | 197890-44-1 |
| Formula | C19H32ClN3O4S |
| Solubility | ≥21.7 mg/mL in DMSO; insoluble in H2O; ≥54.6 mg/mL in EtOH |
| Chemical Name | (3S,3aS,6aR)-3-isopropyl-1-(methylsulfonyl)-4-((E)-4-(piperidin-1-yl)but-2-enoyl)hexahydropyrrolo[3,2-b]pyrrol-2(1H)-one hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | CC([C@@](C1=O)([H])[C@@]2([H])[C@@](N1S(C)(=O)=O)([H])CCN2C(/C([H])=C([H])/CN3CCCCC3)=O)C.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
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化学结构
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