Membrane Transporter/Ion Channel
Ion channels are pore-forming membrane proteins which allow the flow of ions across the membrane. The ion channels can be broadly grouped into six families including calcium channels, chloride channels, potassium channels, sodium channels, gap junction proteins and porins. Not all ion channels are gated, such as certain type of K+ and Cl– channels, transient receptor potential superfamily of cation channels, the ryanodine receptors and the IP3 receptors, but most Na+, K+, Ca2+ and some Cl– channels are all gated by voltage. Ligand-gated channels are regulated in response to ligand binding (e.g. neurotransmitters signaling). These ligand-gated neurotransmitter receptors are known as ionotropic receptors. Various neurotransmitters couple to ionotropic receptors such as glutamate, acetylcholine, glycine, GABA, and serotonin.
- C3505 5-(N,N-dimethyl)-Amiloride (hydrochloride)Summary: NHE1、NHE2和NHE3抑制剂
- C3498 Enniatin Complex中文名: 恩镰孢菌素复合物Summary: 离子载体
- C3410 Oligomycin C中文名: 寡霉素CSummary: 线粒体F1FO-ATP合酶抑制剂
- C3205 Lanicemine中文名: 拉尼西明Summary: 电压依赖性NMDA通道阻断剂
- C3140 Rhodamine 123 (chloride)中文名: 罗丹明123Summary: 膜可渗透的阳离子染料,用作流出泵P-糖蛋白的底物
- C3137 Enniatin B中文名: 恩镰孢菌素 BSummary: 促进K+和Na+穿膜进入的离子载体
- B6102 NS 11394Summary: GABA(A)受体阳性调节剂
- B6077 E-4031Summary: 阻断ATP敏感性钾通道的抗心律不齐药物
- B6065 Calcium Ionophore I中文名: 钙离子载体 ISummary: Ca2+选择性的离子载体
- A8720 MYK-461Summary: 抑制三磷酸腺苷酶的活性