Oligomycin C
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 1mg | ￥6015.00 | 10-15工作日发货 | |
| 5mg | ￥17986.00 | 10-15工作日发货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Oligomycins are the macrolide antibiotics produced by Streptomyces species such as Streptomyces diastatochromogenes, S. libani and S. avermitilis. Oligomycins exihibited a strong toxicity against other organisms, such as Aspergillus niger, Alternaria alternata, Botrytis cinerea and Phytophthora capsici. Oligomycins showed no activity towards bacteria. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism.
Oligomycin C is a minor antifungal compound isolated from Streptomyces strain in soil sample that acts as an inhibitor of the mitochondrial F1FO-ATP synthase [1]. Inhibition of the ATP synthase by oligomycins resulted in cell death [2].
References:
[1]. Yang P W, Li M G, Zhao J Y, et al. Oligomycins A and C, major secondary metabolites isolated from the newly isolated strain Streptomyces diastaticus[J]. Folia microbiologica, 2010, 55(1): 10-16.
[2]. Marton A, Mihalik R, Bratincsák A, et al. Apoptotic cell death induced by inhibitors of energy conservation[J]. European journal of biochemistry, 1997, 250(2): 467-475.
产品性质
| 物理外观 | A white lyophilisate |
| CAS号 | 11052-72-5 |
| 分子式 | C45H74O10 |
| 分子量 | 775.1 |
| 化学名称 | (1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11S,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)-22-ethyl-3',4',5',6'-tetrahydro-7,11,15-trihydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-spiro[2,26-dioxab |
| 溶解度 | Soluble in DMSO |
| SMILES | O=C([C@@H](C)[C@H](O)[C@@H](C)/C=C/1)[C@H](C)[C@@H](O)[C@H](C)C([C@@H](C)[C@@H](O)[C@H](C)C/C=C/C=C/[C@@](CC)([H])CC[C@@]2([H])[C@@H](C)[C@@]([C@H](C)[C@@]3(CC[C@H](C)[C@@](C[C@H](O)C)([H])O3)O2)([H])OC1=O)=O |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 寡霉素 C 是一种从链霉菌株中分离出来的抗真菌剂。 |
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