Membrane Transporter/Ion Channel - Reversible
Ion channels are pore-forming membrane proteins which allow the flow of ions across the membrane. The ion channels can be broadly grouped into six families including calcium channels, chloride channels, potassium channels, sodium channels, gap junction proteins and porins. Not all ion channels are gated, such as certain type of K+ and Cl– channels, transient receptor potential superfamily of cation channels, the ryanodine receptors and the IP3 receptors, but most Na+, K+, Ca2+ and some Cl– channels are all gated by voltage. Ligand-gated channels are regulated in response to ligand binding (e.g. neurotransmitters signaling). These ligand-gated neurotransmitter receptors are known as ionotropic receptors. Various neurotransmitters couple to ionotropic receptors such as glutamate, acetylcholine, glycine, GABA, and serotonin.
- B1393 Nitrendipine中文名: 尼群地平Target: Voltage-gated Calcium Channels (CaV)Summary: 钙通道阻滞剂
- B1387 (-)-Blebbistatin3 Citation中文名: 布雷他汀Target: Myosin II ATPasesSummary: 非肌肉肌球蛋白II型ATP酶抑制剂
- B1087 GlyH-101Target: CFTRSummary: CFTR Inhibitor II
- A1605 Dynasore4 CitationTarget: GTPasesSummary: Dynamin(动力素)GTP酶抑制剂
- A3626 ML-7 hydrochlorideTarget: Myosin light chain kinases (MLCKs)Summary: 肌球蛋白轻链激酶抑制剂