Membrane Transporter/Ion Channel - Type 2 Diabetes
Ion channels are pore-forming membrane proteins which allow the flow of ions across the membrane. The ion channels can be broadly grouped into six families including calcium channels, chloride channels, potassium channels, sodium channels, gap junction proteins and porins. Not all ion channels are gated, such as certain type of K+ and Cl– channels, transient receptor potential superfamily of cation channels, the ryanodine receptors and the IP3 receptors, but most Na+, K+, Ca2+ and some Cl– channels are all gated by voltage. Ligand-gated channels are regulated in response to ligand binding (e.g. neurotransmitters signaling). These ligand-gated neurotransmitter receptors are known as ionotropic receptors. Various neurotransmitters couple to ionotropic receptors such as glutamate, acetylcholine, glycine, GABA, and serotonin.
- B1410 Amlodipine中文名: 氨氯地平Target: Voltage-gated Calcium Channels (CaV)Summary: 钙通道阻滞剂
- B2198 Nateglinide中文名: 那格列奈Target: Inward Rectifier Potassium (Kir) ChannelsSummary: 胰岛素促分泌剂
- B2195 Gliclazide中文名: 格列齐特Target: Inward Rectifier Potassium (Kir) ChannelsSummary: 钾通道抑制剂
- B2194 Tolbutamide中文名: 甲苯磺丁脲Target: cAMP|Sulfonylurea receptorsSummary: 第一代钾通道阻滞剂
- B2193 Mitiglinide Calcium中文名: 米格列奈钙Target: Inward Rectifier Potassium (Kir) ChannelsSummary: 钾通道抑制剂