GSK J5 HCl
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
GSK J5 HCl 是GSK J5的盐酸盐形式。GSK J5是GSK J4的非活性异构体,也是非活性对照GSK J2的细胞可渗透性酯衍生物。赖氨酸特异性脱甲基酶6B(KDM6B),也称为含Jumonji域的蛋白质D3(JMJD3),研究发现KDM6B在AML患者中过表达过高,这些患者的预后较差。KDM6B特异性药理抑制剂GSK-J4在AML细胞系和AML患者新鲜分离的BM单核细胞(MNC)中有着显着诱导抗增殖作用,同时H3K27me3水平也不断提高。GSK-J4还在体外导致细胞凋亡和细胞周期停滞,并在体内减少了AML异种移植小鼠模型的肿瘤负担。值得注意的是,在人AML异种移植小鼠模型中,注射GSK-J4减弱了疾病进展。用GSK-J4治疗主要导致DNA复制和细胞周期相关途径的下调,并阻止了促进癌症关键基因HOX的表达。ChIP-qPCR验证了这些HOX基因转录起始位点中H3K27me3的富集增加[1]。
[1]. Li Y, Zhang M, Sheng M, Zhang P, Chen Z, Xing W, Bai J, Cheng T, Yang FC, Zhou Y. Therapeutic potential of GSK-J4, a histone demethylase KDM6B/JMJD3 inhibitor, for acute myeloid leukemia. J Cancer Res Clin Oncol. 2018 Jun;144(6):1065-1077. doi: 10.1007/s00432-018-2631-7. Epub 2018 Mar 28. PubMed PMID: 29594337; PubMed Central PMCID: PMC5948279.
Storage | Store at -20°C |
M.Wt | 453.96 |
Cas No. | 1394854-51-3 (free base) |
Formula | C24H28ClN5O2 |
Solubility | Soluble in DMSO |
Chemical Name | ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-3-yl)pyrimidin-4-yl)amino)propanoate hydrochloride |
SDF | Download SDF |
Canonical SMILES | CCOC(CCNC1=CC(N2CCC3=CC=CC=C3CC2)=NC(C4=CN=CC=C4)=N1)=O.Cl |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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