Tyrosine Kinase - Insulin-like growth factors (IGFs) - RSK - insulin - Syk
Receptor tyrosine kinases bind to extracellular ligands/growth factors, which promotes receptor dimerization and autophosphorylation of receptor tyrosine residues. This triggers a cascade of downstream events through phosphorylation of intracellular proteins that ultimately transduce the extracellular signal to the nucleus, causing changes in gene expression. Receptor tyrosine kinases include EGFR/ErbB, PDGFR, VEGFR, FGFR and MET subfamilies etc. Dysfunctions in tyrosine phosphorylation are linked to oncogenic transformation. In additions, various adaptor and effector proteins couple to carboxy-terminal of an active kinase. For instance, binding of the GRB2 adaptor protein activates EGFR and MAPK/ERK signaling.
Non-receptor tyrosine kinases involve many well-defined proteins (e.g. the Src family kinases, c-Abl, and Jak kinases) and other kinases which regulates cell growth and differentiation. For example, Src family kinases are curial for activating and inhibitory pathways in the innate immune response.
- B4904 ACTB-1003Target: VEGFR|FGFR|Tie-2|RSK|p70 S6KSummary: FGFR1抑制剂
- B3553 GS-9973Target: SykSummary: Syk抑制剂
- B2284 Fostamatinib (R788)中文名: 福坦替尼Target: SykSummary: 脾酪氨酸激酶(Syk)抑制剂
- A8620 AZD-34633 CitationTarget: ALK|Insulin-like growth factors (IGFs)Summary: ALK/IGF1R抑制剂
- A8546 R4061 CitationTarget: SykSummary: SYK抑制剂
- A8332 R788 disodium中文名: 福他替尼二钠盐Target: SykSummary: Syk的ATP竞争性抑制剂
- A2024 PD168393Target: PDGFR|FGFR|EGFR|PKC|insulinSummary: EGFR抑制剂
- A3736 PRT062607 Hydrochloride1 CitationTarget: SykSummary: SYK抑制剂
- A3227 BAY 61-3606Target: SykSummary: Syk抑制剂