Proteases
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- C3708 L-Leucine 4-methoxy-β-naphthylamide (hydrochloride)Summary: 氨基肽酶M和亮氨酸氨基肽酶的底物
- C3966 Sitagliptin (phosphate)中文名: 磷酸西他列汀Summary: DPP-4抑制剂
- C3931 ResorcinolnaphthaleinSummary: ACE2激活剂
- C3622 TNP-470中文名: 夫马菌素醇,夫马吉欣Summary: 甲硫氨酸氨基肽酶-2(MetAP2)抑制剂
- C3609 (Z-Ala-Ala-Ala-Ala)2Rh110Summary: 荧光弹性蛋白酶底物
- C3492 RamiprilatSummary: 血管紧张素转换酶抑制剂
- C3393 PPACKII (trifluoroacetate salt)Summary: 腺体和血浆激肽释放酶抑制剂
- C3265 2-Guanidinoethylmercaptosuccinic AcidSummary: 羧肽酶E抑制剂
- C3252 Neutrophil Elastase InhibitorSummary: 嗜中性粒细胞弹性蛋白酶抑制剂
- C3232 NNGHSummary: 细胞渗透性,广谱MMP抑制剂