Proteases - Reversible
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- B5780 UAMC 00039 dihydrochlorideTarget: Dipeptidyl-peptidase IISummary: 二肽基肽酶II(DPP-II)抑制剂
- A8650 Saxagliptin中文名: 沙格列汀Target: DPP-4Summary: DPP4抑制剂
- A4424 SID 26681509Target: CathepsinsSummary: 人组织蛋白酶L抑制剂
- A3690 Otamixaban中文名: 奥米沙班Target: Factor XaSummary: 因子Xa抑制剂
- A3284 Cathepsin S inhibitor1 CitationTarget: CathepsinsSummary: 抑制MHCII抗原呈递
- A3244 Bivalirudin TrifluoroacetateTarget: thrombinSummary: 凝血酶抑制剂
- A1925 Caspase-3/7 Inhibitor I2 CitationTarget: CaspasesSummary: Caspase-3/7抑制剂
- A4050 GM 60012 Citation中文名: 伊洛马司他Target: MMPSummary: 广谱MMP抑制剂
- A2585 MG-13226 CitationTarget: ProteasomeSummary: 细胞通透性的、可逆性的蛋白酶体抑制剂。
- A4077 BIBR 953 (Dabigatran, Pradaxa)中文名: 达比加群Summary: 强效的、可逆的直接凝血酶抑制剂