Tyrosine Kinase - PKC - LRRK2 - ErbB-2 - AXL
Receptor tyrosine kinases bind to extracellular ligands/growth factors, which promotes receptor dimerization and autophosphorylation of receptor tyrosine residues. This triggers a cascade of downstream events through phosphorylation of intracellular proteins that ultimately transduce the extracellular signal to the nucleus, causing changes in gene expression. Receptor tyrosine kinases include EGFR/ErbB, PDGFR, VEGFR, FGFR and MET subfamilies etc. Dysfunctions in tyrosine phosphorylation are linked to oncogenic transformation. In additions, various adaptor and effector proteins couple to carboxy-terminal of an active kinase. For instance, binding of the GRB2 adaptor protein activates EGFR and MAPK/ERK signaling.
Non-receptor tyrosine kinases involve many well-defined proteins (e.g. the Src family kinases, c-Abl, and Jak kinases) and other kinases which regulates cell growth and differentiation. For example, Src family kinases are curial for activating and inhibitory pathways in the innate immune response.
- B5940 TP-0903中文名: 度博替尼Target: AXLSummary: AXL受体酪氨酸激酶抑制剂,抗癌药
- B6342 H-7 dihydrochlorideTarget: PKC|PKG|PKA|Myosin light chain kinases (MLCKs)Summary: 蛋白激酶抑制剂
- B4635 CZC-25146Target: LRRK2Summary: LRRK2抑制剂
- B4633 GNE0877Target: LRRK2Summary: LRRK2抑制剂
- B3605 GNE-7915Target: LRRK2Summary: LRRK2抑制剂
- B1262 HG-10-102-011 CitationTarget: LRRK2Summary: LRRK2抑制剂
- A2024 PD168393Target: PDGFR|FGFR|EGFR|PKC|insulinSummary: EGFR抑制剂
- A3967 Lapatinib Ditosylate中文名: 二苯磺酸拉帕替尼Target: EGFR|ErbB-2Summary: EGFR / HER2抑制剂
- A3558 LRRK2-IN-11 CitationTarget: LRRK2|DCLK2Summary: LRRK2抑制剂