HG-10-102-01
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
HG-10-102-01是一种有效的和选择性的富含亮氨酸重复的激酶2（LRRK2）抑制剂，作用于野生型LRRK2和LRRK2 [G1019S]，IC50值分别为20.3 nM和3.2 nM[1]。
HG-10-102-01是一种有效的和选择性的LRRK2抑制剂，作用于野生型LRRK2、LRRK2 [A2016T]、LRRK2 [G2019S+A1016T]和LRRK2 [G1019S]，IC50值分别为20.3 nM、153.7 nM、95.9 nM和3.2 nM。此外，在稳定转染野生型LRRK2和LRRK2 [G2019S]的HEK 293细胞中，HG-10-102-01剂量依赖性地抑制Ser910和Ser935的磷酸化。而且，在HEK293细胞、小鼠Swiss 3T3细胞和小鼠胚胎成纤维细胞中，增加剂量的HG-10-102-01导致相似的内源性LRRK2在Ser910和Ser935位点的去磷酸化[1]。
参考文献：
[1] Choi HG1, Zhang J, Deng X, Hatcher JM, Patricelli MP, Zhao Z, Alessi DR, Gray NS. Brain Penetrant LRRK2 Inhibitor. ACS Med Chem Lett. 2012 Aug 9;3(8):658-662. Epub 2012 Jun 18.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 377.83 |
| Cas No. | 1351758-81-0 |
| Formula | C17H20ClN5O3 |
| Solubility | insoluble in H2O; ≥18.9 mg/mL in DMSO; ≥7.64 mg/mL in EtOH with ultrasonic |
| Chemical Name | (E)-(4-((5-chloro-6-(methylimino)-1,6-dihydropyrimidin-2-yl)amino)-2-methoxyphenyl)(morpholino)methanone |
| SDF | Download SDF |
| Canonical SMILES | C/N=C(N1)\C(Cl)=CN=C1NC2=CC(OC)=C(C(N3CCOCC3)=O)C=C2 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
相关生物数据
