Proteases - HCV Proteases - MMP - Notch
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- B4686 TAPI-12 CitationTarget: MMPSummary: TACE/ADAM17抑制剂
- A5618 Daclatasvir (BMS-790052)中文名: 达卡他韦Target: HCV ProteasesSummary: HCV NS5A抑制剂
- A4442 WAY 170523Target: MMPSummary: MMP-13抑制剂
- A4432 ARP 1001 CitationTarget: MMPSummary: MMP-2抑制剂
- A3820 Simeprevir1 Citation中文名: 西咪匹韦Target: HCV ProteasesSummary: HCV NS3/4A蛋白酶抑制剂
- A4023 LY30394781 CitationTarget: NotchSummary: Notch抑制剂
- A4051 NSC 4050201 CitationTarget: MMPSummary: MT1-MMP抑制剂
- A4050 GM 60012 Citation中文名: 伊洛马司他Target: MMPSummary: 广谱MMP抑制剂
- A4049 Marimastat1 Citation中文名: 马立马司他Target: MMPSummary: MMPs抑制剂
- A4024 Danoprevir (RG7227)中文名: 丹诺瑞韦Target: HCV ProteasesSummary: HCV NS3/4A蛋白酶抑制剂