Proteases - Aminopeptidases - Subtilisin/Kex2p-like proprotein convertase - Thymidylate Synthase - MMP
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- B5437 Decanoyl-RVKR-CMKTarget: Subtilisin/Kex2p-like proprotein convertaseSummary: 枯草杆菌蛋白酶/Kex2p样前蛋白转化酶抑制剂
- B4686 TAPI-12 CitationTarget: MMPSummary: TACE/ADAM17抑制剂
- A8621 Bestatin hydrochloride中文名: 盐酸乌苯美司Target: AminopeptidasesSummary: 氨肽酶N(APN/CD13)和氨肽酶B抑制剂。
- A4442 WAY 170523Target: MMPSummary: MMP-13抑制剂
- A4432 ARP 1001 CitationTarget: MMPSummary: MMP-2抑制剂
- A4355 Tosedostat (CHR2797)1 Citation中文名: 托舍多特Target: AminopeptidasesSummary: 氨肽酶(Aminopeptidase)抑制剂
- A4051 NSC 4050201 CitationTarget: MMPSummary: MT1-MMP抑制剂
- A4050 GM 60012 Citation中文名: 伊洛马司他Target: MMPSummary: 广谱MMP抑制剂
- A4049 Marimastat1 Citation中文名: 马立马司他Target: MMPSummary: MMPs抑制剂
- A4071 Fluorouracil (Adrucil)3 Citation中文名: 氟尿嘧啶Target: Thymidylate SynthaseSummary: 胸苷酸合成酶抑制剂,抗肿瘤药物。