PPAR
The peroxisome proliferator-activated receptors (PPARs), belonging to the nuclear receptor superfamily, are a group of nuclear receptor proteins that are composed of three isoforms, including PPARγ, PPARα and PPARδ, encoded by separate genes. PPARs have a modular structure characterized by the presence of two highly conserved domains, including the DNA binding domain (DBD) of two zinc fingers and the ligand binding domain (LBD) of 13 α-helices and a small 4-stranded β-sheet. PPARs are ligand-regulated transcription factors controlling gene expression by binding to specific response elements (PPREs) within promoters, where PPARs bind as heterodimers with a retinoid X receptor and interact with cofactors upon binding leading to the increasing of rate of transcription initiation.
- B7553 TesaglitazarSummary: 双特异性PPARα/γ激动剂
- B7471 S26948Summary: PPARγ激动剂
- B7406 GSK 0660Summary: PPARδ拮抗剂
- B6929 SR 202Summary: PPARγ拮抗剂
- B6826 GW 7647Summary: PPARα激动剂
- B6691 BADGESummary: PPARγ拮抗剂
- B6681 CiglitazoneSummary: PPARγ激动剂
- B7010 15-deoxy-Δ-12,14-Prostaglandin J2Target: PPARSummary: PPARγ激动剂
- B3610 Clofibrate中文名: 氯贝丁酯Summary: PPAR 激动剂
- B1947 Gemfibrozil中文名: 吉非罗齐Summary: PPARα激活剂