PPAR
The peroxisome proliferator-activated receptors (PPARs), belonging to the nuclear receptor superfamily, are a group of nuclear receptor proteins that are composed of three isoforms, including PPARγ, PPARα and PPARδ, encoded by separate genes. PPARs have a modular structure characterized by the presence of two highly conserved domains, including the DNA binding domain (DBD) of two zinc fingers and the ligand binding domain (LBD) of 13 α-helices and a small 4-stranded β-sheet. PPARs are ligand-regulated transcription factors controlling gene expression by binding to specific response elements (PPREs) within promoters, where PPARs bind as heterodimers with a retinoid X receptor and interact with cofactors upon binding leading to the increasing of rate of transcription initiation.
- C4735 N-Octadecyl-N'-propyl-sulfamideSummary: PPARα激活剂
- C4916 GW 590735Summary: PPARα的有效选择性激动剂
- C4758 DarglitazoneSummary: PPARγ激动剂,具有抗糖尿病作用
- C3986 MuraglitazarSummary: PPARα和PPARγ的双重激动剂
- C3544 BMS 687453Summary: PPARα激动剂
- C3407 GQ-16Summary: PPARγ的部分激动剂
- B6128 Fenofibric acid中文名: 非诺贝特酸Summary: ppar抑制剂,降脂剂
- A8957 AUDASummary: 强效环氧化物水解酶抑制剂/PPARα激活剂
- B5581 SR 1664Summary: 抑制Cdk5介导的PPARγ磷酸化,抗糖尿病药
- B7609 CP 775146Summary: PPARα激动剂