Remodelin
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Remodelin是有效的NAT10抑制剂[1].
N-乙酰转移酶10(NAT10)是唯一被鉴定作用于微管和组蛋白的赖氨酸乙酰转移酶[1].NAT10主要存在于核仁中.
Remodelin是有效的NAT10抑制剂.在核纤层蛋白A/C缺失的(siLMNA)细胞中,remodelin可通过抑制NAT10赖氨酸乙酰转移酶活性改造核结构.在LMNA突变的HGPS患者来源的细胞和原代MRC5成纤维细胞中,Remodelin可显著降低核畸形出现率.在U2OS细胞和正常成纤维细胞中,remodelin可抑制法尼基转移酶抑制剂(FTI)导致的核形缺陷.在HGPS细胞中,remodelin可减少畸形核的数量,表明抑制NAT10可介导核形正常化.并且,remodelin可降低DNA损伤信号,降低核膜上SUN1的积累,降低自磷酸化ATM和DNA双链断裂标记γH2AX水平,并可改善染色质和核仁组织.在siLMNA和HGPS细胞中,remodelin可抑制微管锚定中心体[1].
参考文献：
[1]. Larrieu D, Britton S, Demir M, et al. Chemical inhibition of NAT10 corrects defects of laminopathic cells. Science, 2014, 344(6183): 527-532.
| Storage | Store at -20°C |
| M.Wt | 363.28 |
| Cas No. | 1622921-15-6 |
| Formula | C15H15BrN4S |
| Solubility | ≥36.3 mg/mL in DMSO; insoluble in H2O; ≥2.6 mg/mL in EtOH with ultrasonic |
| Chemical Name | 4-[2-(2-cyclopentylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile;hydrobromide |
| SDF | Download SDF |
| Canonical SMILES | C1CCC(=NNC2=NC(=CS2)C3=CC=C(C=C3)C#N)C1.Br |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
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化学结构
