Aurora Kinase - Cancer
Aurora kinases are a family of serine-threonine kinases of three highly homologous members, including aurora A kinase, aurora B kinase and aurora C kinase, which are responsible for chromosome assembly and segregation during mitosis. Aurora kinases are characterized by two domains: a regulatory domain in the NH2 terminus and a catalytic domain in the COOH terminus, in which an A-Box and a D-Box found correspondingly in each domain are responsible for protein degradation. Aurora A kinase plays an important role in centrosome function and duplication, mitotic entry and bipolar spindle assembly; while Aurora B kinase is the catalytic component of the chromosomal passenger complex regulating the accurate segregation of the chromatids at mitosis, histone modification and cytokinesis. Aurora C kinase is less studied and expressed restrictedly in the testes.
- A4116 Danusertib (PHA-739358)2 Citation中文名: 达鲁舍替Target: Aurora KinasesSummary: Aurora kinase(极光激酶)抑制剂
- A4114 MLN8054Target: Aurora KinasesSummary: Aurora A激酶抑制剂
- A4132 CCT137690Target: Aurora KinasesSummary: Aurora A / B / C抑制剂
- A4130 ENMD-2076Target: Aurora Kinases|FLT3|RET|Src|VEGFR3/FLT4|NTRK1/TRKA|CSF-1R/c-FmsSummary: Aurora A/Flt3的选择性抑制剂
- A4112 Barasertib (AZD1152-HQPA)3 Citation中文名: 巴拉塞替Target: Aurora KinasesSummary: Aurora Kinase B抑制剂
- A4111 VX-680 (MK-0457,Tozasertib)中文名: 陶扎色替Target: Aurora KinasesSummary: Aurora 激酶抑制剂