Cell Cycle/Checkpoint - Neuroblastoma - Colorectal Cancer - Ovarian Cancer
The cell cycle is consisted of 4 main phases: Gap 1 (G1), DNA replication (S), Gap 2 (G2), and mitosis (M). There are “checkpoints” mechanism regulates the transition between these phases, at the G1/S boundary, in the S-phase and during G2/M phases. Cell can only pass through these checkpoints when signaling factors are activated and free of DNA damage. Important proteins that control cell cycle events and checkpoints are cullins, cyclins, cyclin-dependent kinases (Cdks), p53 and their inhibitors etc. Cdks family (Cdk2, Cdk3, Cdk4 and Cdk6) are Ser/Thr kinases that regulate cell cycle progression in association with cyclin binding partners (cyclin D, cyclin E and cyclin A) during all four phases. p53 halts the cell cycle if the DNA is damaged and allowing time for DNA repair to progress; it can also initiate apoptosis if DNA damage is too severe to be repaired.
- B1035 Dolastatin 10中文名: 尾海兔素10Target: Microtubules/TubulinsSummary: 抗肿瘤剂
- B1288 RigosertibTarget: PI3K|PLKSummary: PI3K/PLK1抑制剂
- B1437 PF-477736Target: ChkSummary: Chk1抑制剂
- A8681 Ro3280Target: PLKSummary: PLK1高选择性抑制剂
- A8641 LEE011中文名: 瑞博西利,瑞博西林Target: Cyclin-Dependent KinasesSummary: CDK4/6抑制剂
- A8412 Dinaciclib (SCH727965)2 CitationTarget: Cyclin-Dependent KinasesSummary: CDK抑制剂
- A8477 MK-8776 (SCH-900776)Target: ChkSummary: Chk1高效选择性抑制剂
- A1986 Nu 6027Target: Cyclin-Dependent Kinases|ATM/ATRSummary: 有效的ATR/CDK选择性抑制剂
- A5459 PHA-7938871 CitationTarget: Cyclin-Dependent KinasesSummary: Pan-Cdk抑制剂
- A1630 Epothilone B (EPO906, Patupilone)中文名: 埃博霉素B,帕土匹龙Target: Microtubules/TubulinsSummary: 大环内酯物抗癌试剂