Cell Cycle/Checkpoint - Melanoma - Breast Cancer
The cell cycle is consisted of 4 main phases: Gap 1 (G1), DNA replication (S), Gap 2 (G2), and mitosis (M). There are “checkpoints” mechanism regulates the transition between these phases, at the G1/S boundary, in the S-phase and during G2/M phases. Cell can only pass through these checkpoints when signaling factors are activated and free of DNA damage. Important proteins that control cell cycle events and checkpoints are cullins, cyclins, cyclin-dependent kinases (Cdks), p53 and their inhibitors etc. Cdks family (Cdk2, Cdk3, Cdk4 and Cdk6) are Ser/Thr kinases that regulate cell cycle progression in association with cyclin binding partners (cyclin D, cyclin E and cyclin A) during all four phases. p53 halts the cell cycle if the DNA is damaged and allowing time for DNA repair to progress; it can also initiate apoptosis if DNA damage is too severe to be repaired.
- A8717 THZ21 CitationTarget: Cyclin-Dependent KinasesSummary: CDK7抑制剂
- B1288 RigosertibTarget: PI3K|PLKSummary: PI3K/PLK1抑制剂
- A8641 LEE011中文名: 瑞博西利,瑞博西林Target: Cyclin-Dependent KinasesSummary: CDK4/6抑制剂
- A8624 CGK733Target: ATM/ATRSummary: ATM/ATR抑制剂
- A8335 Palbociclib (PD0332991) Isethionate1 Citation中文名: 帕博西尼羟乙基磺酸盐Target: Cyclin-Dependent KinasesSummary: CDK4/6抑制剂
- A8316 PD 0332991 (Palbociclib) HCl5 Citation中文名: 帕博西尼Target: Cyclin-Dependent KinasesSummary: CDK4/6抑制剂
- A1794 LY2835219中文名: 甲磺酸阿贝西尼Target: Cyclin-Dependent KinasesSummary: CDK4/6抑制剂
- A1986 Nu 6027Target: Cyclin-Dependent Kinases|ATM/ATRSummary: 有效的ATR/CDK选择性抑制剂
- A5919 AZD7762Target: ChkSummary: ATP竞争性的检查点激酶抑制剂
- A5343 Ispinesib (SB-715992)中文名: 伊斯平斯Target: KspSummary: 驱动蛋白纺锤体蛋白(KSP)抑制剂