Cell Cycle/Checkpoint - Cyclin-Dependent Kinases - Src
The cell cycle is consisted of 4 main phases: Gap 1 (G1), DNA replication (S), Gap 2 (G2), and mitosis (M). There are “checkpoints” mechanism regulates the transition between these phases, at the G1/S boundary, in the S-phase and during G2/M phases. Cell can only pass through these checkpoints when signaling factors are activated and free of DNA damage. Important proteins that control cell cycle events and checkpoints are cullins, cyclins, cyclin-dependent kinases (Cdks), p53 and their inhibitors etc. Cdks family (Cdk2, Cdk3, Cdk4 and Cdk6) are Ser/Thr kinases that regulate cell cycle progression in association with cyclin binding partners (cyclin D, cyclin E and cyclin A) during all four phases. p53 halts the cell cycle if the DNA is damaged and allowing time for DNA repair to progress; it can also initiate apoptosis if DNA damage is too severe to be repaired.
- A8565 Purvalanol B1 CitationTarget: Cyclin-Dependent KinasesSummary: CDK1/CDK2/CDK4抑制剂
- A8412 Dinaciclib (SCH727965)2 CitationTarget: Cyclin-Dependent KinasesSummary: CDK抑制剂
- A8385 BMS265246Target: Cyclin-Dependent KinasesSummary: CDK1/2抑制剂
- A8501 PHA-848125中文名: 嘧西利,米尔西利Target: Cyclin-Dependent KinasesSummary: 有效的ATP竞争性CDK抑制剂
- A8335 Palbociclib (PD0332991) Isethionate1 Citation中文名: 帕博西尼羟乙基磺酸盐Target: Cyclin-Dependent KinasesSummary: CDK4/6抑制剂
- A8326 AZD-54382 CitationTarget: Cyclin-Dependent KinasesSummary: CDK1/2/9抑制剂
- A8316 PD 0332991 (Palbociclib) HCl5 Citation中文名: 帕博西尼Target: Cyclin-Dependent KinasesSummary: CDK4/6抑制剂
- A1794 LY2835219中文名: 甲磺酸阿贝西尼Target: Cyclin-Dependent KinasesSummary: CDK4/6抑制剂
- A1986 Nu 6027Target: Cyclin-Dependent Kinases|ATM/ATRSummary: 有效的ATR/CDK选择性抑制剂
- A5719 AT7519Target: Cyclin-Dependent KinasesSummary: CDK抑制剂