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Bardoxolone

巴多索隆
Catalog No.
A3220
用于治疗慢性肾病,每天一次
组合的产品项目
规格价格库存 数量
50mg
¥ 1,790.00
现货
500mg
¥ 7,163.00
现货

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A

背景

Bardoxolone methyl, previously known as RTA 402, is the lead molecule in Reata's portfolio of Antioxidant Inflammation Modulators (AIMs). The AIMs are potent inducers of the transcription factor Nrf2, an important biological target that controls the production of many of the body's antioxidant and detoxification enzymes. Because oxidative stress and inflammation occur throughout the course of chronic kidney disease (CKD) and are known to contribute to loss of kidney function, agents that activate the Nrf2 pathway in patients with CKD may provide a novel method for preserving or improving kidney function. Bardoxolone methyl is currently being investigated as a potential oral once-a-day treatment for CKD.

化学属性

Physical AppearanceA solid
StorageStore at -20°C
M.Wt491.66
Cas No.218600-44-3
FormulaC31H41NO4
SynonymsCDDO;RTA 401;RTA401;RTA-401
Solubility≥49.2 mg/mL in DMSO; insoluble in H2O; ≥2.682 mg/mL in EtOH with gentle warming and ultrasonic
Chemical Name(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-carboxylic acid
SDFDownload SDF
Canonical SMILESCC1(CCC2(CCC3(C(C2C1)C(=O)C=C4C3(CCC5C4(C=C(C(=O)C5(C)C)C#N)C)C)C)C(=O)O)C
运输条件 蓝冰运输或根据您的需求运输。
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