KEAP1-Nrf2 - Cell Experiments
The KEAP1-Nrf2 pathway is the major regulator of cytoprotective responses to chemical and/or oxidative stresses caused by reactive oxygen species (ROS) and electrophiles. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that binds together with small Maf proteins to the antioxidant response element (ARE) in the regulatory regions of cellular defense enzyme genes leading to the activation of a wide rang of cell defense processes; while KEAP1 (Kelch ECH associating protein 1), a negative repressor of Nrf2, is an adaptor protein for a Cul3-based ubiqutitin E3 ligase that binds to Nrf2 and promotes its degradation by the ubiquitin proteasome pathway.
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- C4733 Sulforaphane中文名: 萝卜硫素Summary: 通过Keap1-Nrf2信号传导的化学预防酶诱导剂
- A3335 Curcumin1 Citation中文名: 姜黄素Target: Histone Deacetylases (HDACs)|Nrf2|Histone Acetyltransferases (HATs)|TyrosinasesSummary: Tyrosinase(酪氨酸酶)抑制剂
- N2172 5,7-dihydroxychromone1 Citation中文名: 5,7-二羟基色酮Target: Nrf2/ARE signal|PPARSummary: Nrf2/ARE信号激活剂和PPARγ激动剂