Tyrosine Kinase - LRRK2 - Lyn - ITK - Trk Receptors
Receptor tyrosine kinases bind to extracellular ligands/growth factors, which promotes receptor dimerization and autophosphorylation of receptor tyrosine residues. This triggers a cascade of downstream events through phosphorylation of intracellular proteins that ultimately transduce the extracellular signal to the nucleus, causing changes in gene expression. Receptor tyrosine kinases include EGFR/ErbB, PDGFR, VEGFR, FGFR and MET subfamilies etc. Dysfunctions in tyrosine phosphorylation are linked to oncogenic transformation. In additions, various adaptor and effector proteins couple to carboxy-terminal of an active kinase. For instance, binding of the GRB2 adaptor protein activates EGFR and MAPK/ERK signaling.
Non-receptor tyrosine kinases involve many well-defined proteins (e.g. the Src family kinases, c-Abl, and Jak kinases) and other kinases which regulates cell growth and differentiation. For example, Src family kinases are curial for activating and inhibitory pathways in the innate immune response.
- B5859 Entrectinib中文名: 恩曲替尼Target: Trk Receptors|ALK|ROS1Summary: ALK激酶抑制剂
- B5839 SU6656Target: Src|Lyn|YES|FynSummary: Src 酪氨酸激酶抑制剂
- B5832 Altiratinib1 CitationTarget: FLT3|VEGFR|Trk Receptors|c-MET|Tie-2Summary: c-MET/TIE-2/VEGFR抑制剂
- B5712 ANA 121 CitationTarget: Trk ReceptorsSummary: TrkB受体拮抗剂
- B4635 CZC-25146Target: LRRK2Summary: LRRK2抑制剂
- B4633 GNE0877Target: LRRK2Summary: LRRK2抑制剂
- B3605 GNE-7915Target: LRRK2Summary: LRRK2抑制剂
- B2297 GW4417561 CitationTarget: Trk ReceptorsSummary: TrkA抑制剂
- B1262 HG-10-102-011 CitationTarget: LRRK2Summary: LRRK2抑制剂
- A8303 GNF-5837Target: Trk ReceptorsSummary: Pan-Trk抑制剂