Stem Cell - GLI - TNKS - Smoothened
In ESC, BMP/TGF-β signaling pathway plays a key role in maintaining pluripotency and self-renewal. It signals through Smad proteins, and the FGF signaling pathway, which activates the MAPK and Akt pathways. The Wnt signaling pathway also promotes pluripotency. OCT-4, SOX2, and NANOG are three main transcription factors that are expressed and activated by these pathways. Induced pluripotent stem cells (iPSC) are pluripotent cells that can be generated from differentiated cells with forced expression of specific reprogramming factors. Both ESC and iPSC can be induced to develop into distinct cell types that associated with three primary germ layers: ectoderm, mesoderm and endoderm. Signaling pathways that control the development of these cell lineages, including BMP/TGF-β, Notch, Wnt/β-catenin, Hedgehog and Hippo pathways, which regulate cell division, growth and differentiation. Defects in stem cell signaling are related to developmental disorders and cancer.
- B2266 LDE225 (NVP-LDE225,Erismodegib)1 Citation中文名: 索尼德吉Target: SmoothenedSummary: Smoothened抑制剂
- B3283 PF-04449913中文名: 格拉吉布Target: SmoothenedSummary: Smoothened拮抗剂
- A8340 Cyclopamine1 Citation中文名: 环巴胺Target: SmoothenedSummary: Hedgehog (Hh)信号抑制剂
- A1615 GANT611 CitationTarget: GLISummary: GLI拮抗剂
- A1877 XAV-9391 CitationTarget: TNKSSummary: Tankyrase 1/2抑制剂
- A3543 LDE225 DiphosphateTarget: SmoothenedSummary: Smo拮抗剂
- A3258 BMS-833923Target: SmoothenedSummary: Smoothened抑制剂