Membrane Transporter/Ion Channel - Voltage-gated Potassium (KV) Channels - Calcium-activated chloride channels (CaCC) - GABAB Receptors - NHE - P-glycoprotein (P-gp)
Ion channels are pore-forming membrane proteins which allow the flow of ions across the membrane. The ion channels can be broadly grouped into six families including calcium channels, chloride channels, potassium channels, sodium channels, gap junction proteins and porins. Not all ion channels are gated, such as certain type of K+ and Cl– channels, transient receptor potential superfamily of cation channels, the ryanodine receptors and the IP3 receptors, but most Na+, K+, Ca2+ and some Cl– channels are all gated by voltage. Ligand-gated channels are regulated in response to ligand binding (e.g. neurotransmitters signaling). These ligand-gated neurotransmitter receptors are known as ionotropic receptors. Various neurotransmitters couple to ionotropic receptors such as glutamate, acetylcholine, glycine, GABA, and serotonin.
- B5895 CARIPORIDE中文名: 卡立泊来德Target: NHESummary: 有效的NHE抑制剂
- B5086 CGP 55845 hydrochlorideTarget: GABAB ReceptorsSummary: GABAB受体拮抗剂
- B7659 Psora 41 CitationTarget: Voltage-gated Potassium (KV) ChannelsSummary: Kv1.3阻断剂
- B6367 NPPBTarget: Calcium-activated chloride channels (CaCC)|GPR35Summary: 氯离子通道抑制剂
- B2278 Ibutilide Fumarate中文名: 富马酸伊布利特Target: Voltage-gated Potassium (KV) Channels|Voltage-gated Calcium Channels (CaV)|sodium channelSummary: III类抗心律失常药物
- B1531 (R)-baclofen中文名: (R)-巴氯芬Target: GABAB ReceptorsSummary: GABA受体激动剂
- A8549 LY335979 (Zosuquidar 3HCL)1 Citation中文名: 唑喹达三盐酸盐Target: P-glycoprotein (P-gp)Summary: Pgb(P糖蛋白)抑制剂
- A3956 ZosuquidarTarget: P-glycoprotein (P-gp)|Cytochrome P450 (CYP450)Summary: MDR调节剂
- A3859 Tariquidar methanesulfonate, hydrate中文名: 他立喹达二甲磺酸盐六水合物Target: P-glycoprotein (P-gp)Summary: P-糖蛋白抑制剂
- A8208 Tariquidar2 Citation中文名: 他立喹达Target: P-glycoprotein (P-gp)Summary: P-糖蛋白抑制剂