CARIPORIDE
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
CARIPORIDE对NHE1\NHE3和NHE2的IC50值分别为0.05 μM\3 μM和1000 μM.
Na-H交换(NHE)是心肌缺血再灌注损伤发展的一种重要机制.其抑制剂可以纠正上述病理损伤相关的离子失衡,从而保护缺血再灌注心脏.Cariporide是一种有效的NHE抑制剂.
体外:Cariporide呈浓度依赖性地抑制兔红细胞中的Amiloride敏感性钠内流\减少细胞酸化引起的人血小板肿胀并减慢大鼠心肌pH值的恢复[1].
体内:于冠状动脉结扎前,静脉注射和口服给予麻醉大鼠Cariporide可以呈剂量依赖性地减少或完全阻止室性早搏\心室颤动以及室性心动过速.此化合物耐受性良好,具有适中的循环变量[1].
临床试验:对Cariporide进行了II/III期大剂量探索试验,以评估其对急性冠脉综合征的疗效.总体结果未能证明其预防作用.亚组分析显示,最高剂量的Cariporide显著降低风险,特别是针对进行冠状动脉搭桥手术的高风险患者[2].
参考文献:
[1] Scholz W, Albus U, Counillon L, Ggelein H, Lang HJ, Linz W, Weichert A, Schlkens BA. Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion. Cardiovasc Res. 1995 Feb;29(2):260-8.
[2] Karmazyn M. Pharmacology and clinical assessment of cariporide for the treatment coronary artery diseases. Expert Opin Investig Drugs. 2000 May;9(5):1099-108.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 283.35 |
Cas No. | 159138-80-4 |
Formula | C12H17N3O3S |
Solubility | insoluble in H2O; ≥12.05 mg/mL in DMSO; ≥2.675 mg/mL in EtOH with gentle warming and ultrasonic |
Chemical Name | (Z)-N-carbamimidoyl-4-isopropyl-3-(methylsulfonyl)benzimidic acid |
SDF | Download SDF |
Canonical SMILES | CC(C1=C(S(C)(=O)=O)C=C(/C(O)=N/C(N)=N)C=C1)C |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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