Membrane Transporter/Ion Channel - Selective - Animal Experiments
Ion channels are pore-forming membrane proteins which allow the flow of ions across the membrane. The ion channels can be broadly grouped into six families including calcium channels, chloride channels, potassium channels, sodium channels, gap junction proteins and porins. Not all ion channels are gated, such as certain type of K+ and Cl– channels, transient receptor potential superfamily of cation channels, the ryanodine receptors and the IP3 receptors, but most Na+, K+, Ca2+ and some Cl– channels are all gated by voltage. Ligand-gated channels are regulated in response to ligand binding (e.g. neurotransmitters signaling). These ligand-gated neurotransmitter receptors are known as ionotropic receptors. Various neurotransmitters couple to ionotropic receptors such as glutamate, acetylcholine, glycine, GABA, and serotonin.
- B4798 Procainamide HCl中文名: 盐酸普鲁卡因胺Target: DNA MethyltransferasesSummary: 钠通道阻滞剂
- B5086 CGP 55845 hydrochlorideTarget: GABAB ReceptorsSummary: GABAB受体拮抗剂
- B7659 Psora 41 CitationTarget: Voltage-gated Potassium (KV) ChannelsSummary: Kv1.3阻断剂
- B7388 Valinomycin中文名: 缬氨霉素Target: IonophoresSummary: 钾离子特异性转运体
- B5351 SNX 482Target: Voltage-gated Calcium Channels (CaV)Summary: 电压依赖性R型CaV2.3钙通道阻滞剂
- B7705 Lithium carbonate中文名: 碳酸锂Target: Na /K ATPasesSummary: Na+/K+ ATPase抑制剂
- B7590 Quinidine中文名: 奎尼丁Target: Voltage-gated Sodium (NaV) Channels|Cytochrome P450 (CYP450)Summary: 降低Na+和K+通道电流
- B6947 Ionomycin free acid中文名: 离子霉素Target: Calcium ionophoresSummary: 钙离子载体
- B6831 Autocamtide-2-related inhibitory peptideTarget: Ca2 /calmodulin-dependent protein kinases (CaMKs)Summary: 钙调蛋白依赖性蛋白激酶II(CaM激酶II,CaMKII)抑制剂
- B6367 NPPBTarget: Calcium-activated chloride channels (CaCC)|GPR35Summary: 氯离子通道抑制剂