Quinidine
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 1mL(10 mM in DMSO) | ￥500.00 | 现货 | |
| 50mg | ￥272.00 | 现货 | |
| 250mg | ￥818.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Quinidine is a clinical antiarrhythmic drug, which is used to treat abnormal heart rhythms and malaria[1].
The application of quinidine in the bath results in a dose-dependent decrease in the peak amplitude of Ik. Kd for Ik block at 0 mV is estimated to be 41 μM[1].
In rats, quinidine inhibits metabolism of amphetamine. Quinidine pretreatment significantly reduces excretion of p-hydroxyamphetamine at 24 and 48 hours, to 7.2% and 24.1% of vehicle control levels, and significantly increases excretion of amphetamine between 24 and 48 hours to 542%[2].
Reference:
[1]. Kehl S J, et al. Quinidine-induced inhibition of the fast transient outward K+ current in rat melanotrophs. Br J Pharmacol, 1991, 103(3): 1807-13.
[2]. Moody D E, et al. Quinidine inhibits in vivo metabolism of amphetamine in rats: impact upon correlation between GC/MS and immunoassay findings in rat urine. J Anal Toxicol, 1990, 14(5): 311-7.
产品性质
| 物理外观 | A solid |
| CAS号 | 56-54-2 |
| 分子式 | C20H24N2O2 |
| 分子量 | 324.42 |
| 小分子别名 | Quinidine (15% dihydroquinidine) |
| 化学名称 | (R)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5S)-5-vinylquinuclidin-2-yl)methanol |
| 溶解度 | insoluble in H2O; ≥10.32 mg/mL in EtOH with ultrasonic; ≥11.95 mg/mL in DMSO |
| SMILES | COc(cc1)cc2c1nccc2[C@H]([C@@H](C[C@@H]1CC2)N2C[C@H]1C=C)O |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 奎尼丁（15% 双氢奎尼丁）是一种抗心律失常药。奎尼丁是一种强效的口服活性选择性细胞色素 P450db 抑制剂。奎尼丁还是一种 K+ 通道阻滞剂，其 IC50 值为 19.9 μM，可诱导细胞凋亡。奎尼丁可用于疟疾研究。 |
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