Chromatin/Epigenetics - MEK - SK - Histone Deacetylases (HDACs) - phosphatases
Epigenetics is the heritable modifications in gene expression that is not associated with changes in DNA sequence. Epigenetic modifications occur mostly on DNA or on the histone octamer. There are several types of epigenetics modifications, DNA methylation by DNA-methyl transferase (DNMT) and covalent modification of histones (e.g. acetylation, methylation, phosphorylation and ubiquitination). Histone acetylation by histone acetyltransferases (HATs) is involved in transcriptional activation, whereas histone deacetylation by histone deacetylases (HDACs) is connected with transcriptional repression. Histone demethylation is associated with lysine-specific demethylase (LSD) and JmjC domain containing histone demethylase (JHDM).
The nucleosome is consisted of four histone proteins (H2A, H2B, H3, and H4), they are primary building block of chromatin. The addition and removal of specific chemical groups refers to as epigenetic marks, it regulates chromatin structure and affects gene expression. Moreover, RNA is intimately involved in the formation of a repressive chromatin state.
Epigenetic mechanism responds to environmental changes at the cellular level and thus influences cellular plasticity. Chromatin and epigenetic regulation play a significant role in the programming of the genome during development and stress response, defects in epigenetics can lead to cancer, inflammation and metabolic disorders etc.
- A8708 Sephin11 CitationTarget: phosphatasesSummary: PPP1R15A抑制剂
- B4890 HPOB1 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC6抑制剂
- B3704 Nexturastat ATarget: Histone Deacetylases (HDACs)Summary: HDAC6抑制剂
- B1182 ABC294640中文名: 奥帕尼布Target: SKSummary: 鞘氨醇激酶2抑制剂
- B1251 Valproic acid中文名: 丙戊酸Target: Histone Deacetylases (HDACs)Summary: HDAC1抑制剂
- A8803 RGFP9664 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC3抑制剂
- A8547 Tubastatin A HCl1 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC6(组蛋白去乙酰化酶6)抑制剂
- A4500 TCS HDAC6 20b1 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC6的选择性抑制剂
- A4498 SBHA1 CitationTarget: Histone Deacetylases (HDACs)Summary: 细胞渗透性HDAC1/HDAC3抑制剂
- A4501 Tubacin3 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC6有效的、选择性、可逆的、细胞通透性的抑制剂。