Cell Cycle/Checkpoint - NTRK1/TRKA - FLT3 - PKA - PLK
The cell cycle is consisted of 4 main phases: Gap 1 (G1), DNA replication (S), Gap 2 (G2), and mitosis (M). There are “checkpoints” mechanism regulates the transition between these phases, at the G1/S boundary, in the S-phase and during G2/M phases. Cell can only pass through these checkpoints when signaling factors are activated and free of DNA damage. Important proteins that control cell cycle events and checkpoints are cullins, cyclins, cyclin-dependent kinases (Cdks), p53 and their inhibitors etc. Cdks family (Cdk2, Cdk3, Cdk4 and Cdk6) are Ser/Thr kinases that regulate cell cycle progression in association with cyclin binding partners (cyclin D, cyclin E and cyclin A) during all four phases. p53 halts the cell cycle if the DNA is damaged and allowing time for DNA repair to progress; it can also initiate apoptosis if DNA damage is too severe to be repaired.
- B5860 TAK960Target: PLKSummary: PLK1抑制剂
- B5857 SBE 13 HClTarget: PLKSummary: 不活跃Plk1的抑制剂
- B4094 NMS-1286937Target: PLKSummary: PLK1抑制剂
- B3523 Fasudil中文名: 法舒地尔Target: ROCK|PKC|PKG|PKA|Myosin light chain kinases (MLCKs)Summary: 钙拮抗剂
- B1288 RigosertibTarget: PI3K|PLKSummary: PI3K/PLK1抑制剂
- B3277 AMG 925Target: Cyclin-Dependent Kinases|FLT3Summary: FLT3/CDK4抑制剂
- A8681 Ro3280Target: PLKSummary: PLK1高选择性抑制剂
- A8680 MLN0905Target: PLKSummary: PLK1抑制剂
- A8394 CHIR-124Target: FLT3|GSK-3|Chk|PDGFRSummary: Chk1抑制剂
- A8441 GSK4613643 CitationTarget: PLKSummary: Plk1抑制剂