Cell Cycle/Checkpoint - FLT3 - ATM/ATR - RAD51
The cell cycle is consisted of 4 main phases: Gap 1 (G1), DNA replication (S), Gap 2 (G2), and mitosis (M). There are “checkpoints” mechanism regulates the transition between these phases, at the G1/S boundary, in the S-phase and during G2/M phases. Cell can only pass through these checkpoints when signaling factors are activated and free of DNA damage. Important proteins that control cell cycle events and checkpoints are cullins, cyclins, cyclin-dependent kinases (Cdks), p53 and their inhibitors etc. Cdks family (Cdk2, Cdk3, Cdk4 and Cdk6) are Ser/Thr kinases that regulate cell cycle progression in association with cyclin binding partners (cyclin D, cyclin E and cyclin A) during all four phases. p53 halts the cell cycle if the DNA is damaged and allowing time for DNA repair to progress; it can also initiate apoptosis if DNA damage is too severe to be repaired.
- B5881 RI-2Target: RAD51Summary: RAD51抑制剂
- B3277 AMG 925Target: Cyclin-Dependent Kinases|FLT3Summary: FLT3/CDK4抑制剂
- B1383 VE-8222 CitationTarget: ATM/ATRSummary: ATR抑制剂
- A8626 ETP-46464Target: PI3K|mTOR|DNA-PK|ATM/ATRSummary: ATR抑制剂
- A8624 CGK733Target: ATM/ATRSummary: ATM/ATR抑制剂
- A8394 CHIR-124Target: FLT3|GSK-3|Chk|PDGFRSummary: Chk1抑制剂
- A8336 KU-600192 CitationTarget: ATM/ATRSummary: ATM激酶抑制剂
- A1986 Nu 6027Target: Cyclin-Dependent Kinases|ATM/ATRSummary: 有效的ATR/CDK选择性抑制剂
- A3764 RI-1Target: RAD51Summary: RAD51抑制剂
- A3210 AZ201 CitationTarget: ATM/ATRSummary: ATR抑制剂