Cell Cycle/Checkpoint - Arp2/3 complex - Fyn - Cyclin-Dependent Kinases - Ksp - RET
The cell cycle is consisted of 4 main phases: Gap 1 (G1), DNA replication (S), Gap 2 (G2), and mitosis (M). There are “checkpoints” mechanism regulates the transition between these phases, at the G1/S boundary, in the S-phase and during G2/M phases. Cell can only pass through these checkpoints when signaling factors are activated and free of DNA damage. Important proteins that control cell cycle events and checkpoints are cullins, cyclins, cyclin-dependent kinases (Cdks), p53 and their inhibitors etc. Cdks family (Cdk2, Cdk3, Cdk4 and Cdk6) are Ser/Thr kinases that regulate cell cycle progression in association with cyclin binding partners (cyclin D, cyclin E and cyclin A) during all four phases. p53 halts the cell cycle if the DNA is damaged and allowing time for DNA repair to progress; it can also initiate apoptosis if DNA damage is too severe to be repaired.
- A8717 THZ21 CitationTarget: Cyclin-Dependent KinasesSummary: CDK7抑制剂
- A8736 THZ531Target: Cyclin-Dependent KinasesSummary: CDK12 和CDK13共价抑制剂
- A8885 Ro 33064 CitationTarget: Cyclin-Dependent KinasesSummary: CDK1抑制剂
- B4754 LDC0000672 CitationTarget: Cyclin-Dependent KinasesSummary: 高特异性的CDK9抑制剂
- B6935 Aminopurvalanol ATarget: Cyclin-Dependent KinasesSummary: 细胞周期蛋白依赖性激酶抑制剂
- B4736 THZ1 HydrochlorideTarget: Cyclin-Dependent KinasesSummary: CDK7抑制剂
- A8882 THZ112 CitationTarget: Cyclin-Dependent KinasesSummary: CDK7共价抑制剂
- B3277 AMG 925Target: Cyclin-Dependent Kinases|FLT3Summary: FLT3/CDK4抑制剂
- B3058 CK-6361 CitationTarget: Arp2/3 complexSummary: Arp2/3复合体抑制剂
- A8642 R5472 CitationTarget: Cyclin-Dependent KinasesSummary: CDK1/2/4抑制剂