Proteasome - Cancer - Neuroblastoma - Colon Carcinoma
The proteasome is a large multisubunit complex of approximately 2.5 MDa that mediates a wide range of physiological and pathological cellular processes by selectively degrading unnecessary proteins in eukaryotes. The structure of a proteasome is comprised of the catalytic core particle (CP) and two terminal regulatory particles (RPs). The CP (also known as the 20S proteasome) is a barrel shaped multisubunit complex (approximately 750 kDa) consisting of four axially stacked heptameric rings (two outer α-rings and two inner β-rings) with 7 subunits in each ring, where three β subunits (β1, β2 and β5) contain catalytically active threonine residues and are associated with caspase-like, trypsin-like and chymotrypsin-like activities respectively.
- B6026 VR23Target: ProteasomeSummary: 蛋白酶抑制剂
- A4443 Gliotoxin1 CitationTarget: 20S proteasomal chymotrypsin|Geranylgeranyltransferase I|FarnesyltransferaseSummary: 20S蛋白酶体抑制剂
- A1933 Carfilzomib (PR-171)10 Citation中文名: 卡非佐米Target: ProteasomeSummary: 蛋白酶体抑制剂
- A2614 Bortezomib (PS-341)24 Citation中文名: 硼替佐米Target: ProteasomeSummary: 蛋白酶体抑制剂
- A4010 Salinosporamide A (NPI-0052, Marizomib)Target: ProteasomeSummary: 20S蛋白酶体抑制剂
- A2585 MG-13226 CitationTarget: ProteasomeSummary: 细胞通透性的、可逆性的蛋白酶体抑制剂。
- A2606 Epoxomicin25 Citation中文名: 环氧酶素Summary: 蛋白酶体抑制剂
- A2583 Lactacystin (Synthetic)1 Citation中文名: 蛋白酶体抑制剂Target: ProteasomeSummary: 蛋白酶体抑制剂
- A2604 Celastrol中文名: 雷公藤红素Target: ProteasomeSummary: 抗氧化、抗炎和免疫抑制剂
- A4007 MLN97083 Citation中文名: 柠檬酸伊沙佐米Target: ProteasomeSummary: 蛋白酶体抑制剂